KEY WORDS | epigenetic plasticity, mental health, neuroscience |
CITY | Strasbourg |
COUNTRY | France |
DETAILS OF THE OFFER | Working place: Institute of Cellular and Integrative Neuroscience (INCI, CNRS UPR3212) Missions: The recruited fellow will join our project dedicated to the understanding of epigenetic plasticity in substance use disorders, or addiction. Our work mostly focuses on DNA methylation (WGBS, EM-seq) and histone modifications (Cut&Tag), with an emphasis on sex-differences. The originality of the project resides in complementary studies conducted in humans and mice. In Human, we will investigate post-mortem brain tissue from addicted individuals carefully characterized through psychological autopsy (collaboration with the Montréal Brain Bank). In the mouse, we will model volitional reward-seeking and compulsive behaviors in operant paradigms, and manipulate the epigenetic enzymatic machinery (conditional knockout of DNA methyltransferases). The recruited fellow will be mainly responsible for molecular biology work, processing of biological samples, and preparation of NGS libraries. A dedicated staff and collaborations are already in place for behavioral modelling (Dr Emmanuel Darcq, CRBS, Strasbourg) and bioinformatic data processing (Dr Anais Bardet, IGBMC, Strasbourg). Qualifications:
A molecular biologist with:
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TYPE OF JOB | Post-doctoral Position |
TYPE OF CONTRACT | CDD (temporary / 24 months) |
REMUNERATION | Depending on experience; full health and social coverage included |
APPLICATION DEADLINE | 31 DEC 2023 |
EMPLOYMENT START DATE | 15 OCT 2023 (flexible, ideally OCT– NOV 2023) |