International PhD offer in physics for ophtalmology

KEY WORDS

physics ,  ophtalmology , neuroscience

CITY

Paris

COUNTRY

France

DETAILS OF THE OFFER

Working place: Institut de la vision

Missions:

Full field optical coherence tomography (FFOCT) is a technology developed in Paris by Kate Grieve’s team which allows cellular level resolution for retinal imaging in the living human eye, in a compact low-cost setup without the need for a complex adaptive optics path. Two prototypes are currently being used in clinical study at the 15-20 Hospital in Paris. The current project aims to transfer this novel technology outside of France for the first time, to the University of Pittsburgh. The equipment is currently being installed, and this project will allow a PhD student to carry out a research project which involves patient imaging with FFOCT, searching for the pertinent clinical biomarkers made accessible by this new technology. It offers the opportunity to diffuse a promising technology within the unique environment formed by the Kate Grieve and Ethan Rossi labs’ parallel high resolution retinal imaging facilities for patient diagnostics and follow-up. The student will benefit from the existing close collaboration of the two teams to develop and enhance multimodal image validation protocols and image analysis methods in order to evaluate the added value of the new technology in improving patient care.

The project proposed seeks to recruit a PhD student, with an ophthalmology and/or optics and/or image processing background, fluent in English, who will bridge the work at the two sites on the early use of this new technique on healthy volunteers and patients, with the following objectives :

1. Generate data with the new device at both sites ;
2. Validate the new technology against the gold standard(s) of retinal imaging at cellular resolution, i.e. adaptive optics and OCT technologies ;
3. Develop software and image analysis protocols to extract novel micrometric biomarkers of retinal disease from the FFOCT images generated in the various cohorts being followed at the two sites. This will include a search for photoreceptor, nerve fiber, vascular and immune biomarkers;

Other:

Job locations :

France : Kate Grieve Team - The Vision Institute, 17 Rue Moreau, 75012 Paris

USA : Ethan Rossi Lab - University of Pittsburgh, 203 Lothrop St. Suite 834, PA 15213 USA

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TYPE OF JOB

Thèse - PhD

TYPE OF CONTRACT

CDD (temporary / 36 months)

APPLICATION DEADLINE

30 JUN 2023

EMPLOYMENT START DATE

1 OCT 2023