Deciphering metabolic intratumoral heterogeneity in idh1 mutant gliomas to propose new therapeutic avenues

KEY WORDS

CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place: IRCM - Institut de Recherche en Cancérologie de Montpellier

Missions:

Gliomas are the most common primary brain tumors affecting approximately 4,000 new patients annually in France. While half of all gliomas are diagnosed as advanced glioblastoma (grade IV), 15% of tumors are detected as grade II diffuse low-grade gliomas (dLGG). These dLGGs mainly affect young adults and the overall survival is 5 to 15 years after diagnosis. Despite surgery, their diffuse nature and their presence in sensitive areas imply the presence of residual cells that will inexorably progress to a very aggressive grade III or IV. It is therefore essential to better characterize dLGGs in order to facilitate the development of new therapies.

The objective of our project is to determine the metabolic specificities of the different subpopulations present in dLGGs to better understand how molecular, cellular and metabolic heterogeneity are orchestrated. As 2-HG leads to important epigenetic and epitranscriptomic consequences, we will also focus on the link between the observed metabolic dysregulations and the epigenome and epitranscriptome

Qualifications:

We are looking for a highly motivated student who will be involved in a new research program of the laboratory aiming at characterizing metabolic heterogeneity in IDH mutated gliomas. He/she will have to show a strong team spirit to integrate a cohesive and enthousiastic team (3 seniors, 3 post-docs, 2 PhD students, M1/M2, 3 engineers...) with transverse competences, as well as develop a close communication with his/her co-director, Pr JP Hugnot and his team at the IGF. The candidate will benefit from the technical and scientific support of the other members of the two teams in a stimulating environment ideal for developing his/her scientific mind. A first experience, or if not, a particular interest in the study of metabolism and/or brain tumors would be appreciated

TYPE OF JOB

Thèse - PhD

TYPE OF CONTRACT

EMPLOYMENT START DATE