Post-doctoral position - Epigenomic mechanisms of drug addiction

KEY WORDS

CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place: Institute of Cellular and Integrative Neuroscience (INCI)

Missions:

The recruited fellow will join our project dedicated to the understanding of epigenetic plasticity in substance use disorders, or addiction. Our work mostly focuses on DNA methylation (WGBS, EM-seq) and histone modifications (Cut&Tag), with an emphasis on sex-differences. The originality of the project resides in complementary studies conducted in humans and mice. In Human, we will investigate post-mortem brain tissue from addicted individuals carefully characterized through psychological autopsy (collaboration with the Montréal Brain Bank). In the mouse, we will model volitional reward-seeking and compulsive behaviors in operant paradigms, and manipulate the epigenetic enzymatic machinery (conditional knockout of DNA methyltransferases). The recruited fellow will be mainly responsible for molecular biology work, processing of biological samples, and preparation of NGS libraries. A dedicated staff and collaborations are already in place for behavioral modelling (Dr Emmanuel Darcq, CRBS, Strasbourg) and bioinformatic data processing (Dr Anais Bardet, IGBMC, Strasbourg).

Qualifications:

A molecular biologist with:

• Experience in the use of next-generation sequencing for epigenomic analysis,
• Strong interest in neuroscience and mental health.

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TYPE OF JOB

TYPE OF CONTRACT

CDD (temporary / 24 months)

REMUNERATION

APPLICATION DEADLINE

EMPLOYMENT START DATE

15 OCT 2023