Post-doc or Research Engineer position on Computational modeling of genetic mutations at cellular level

KEY WORDS

CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place: INSERM U1099 Laboratoire du Traitement du Signal et de l'Image (LTSI) / the University of Rennes

Missions:

Context. Developmental and epileptic encephalopathies (DEEs) are a group of severe rare diseases where the combined effect of seizures, most often drug resistant, and the non-seizures consequences of the disease etiology, often genetic, entail a debilitating encephalopathy with drastic effects on the neurodevelopmental, psychiatric, and motor abilities of the patients. DEEs due to potassium channel mutations (K-DEEs) are emblematic of this disease presentation.

Qualifiactions:

The research project is at the interface between biomathematics (neuro-inspired models) and neuroscience/neurology (epilepsy). The Post-doc/Engineer fellow (PhD level) will preferably have a strong background in computational neuroscience/systems biology or in electrical engineering with experience in bio-signal processing. Knowledge in electrophysiology and/or EEG analysis would be an asset.

The objective of the proposed research position is to design novel neuro-inspired models taking into account the molecular effect of a gene mutation on the specific voltage-gated potassium (K) channel function and the specific phenotypes observed in patients (scalp-recorded EEG signals) and in genetically-modified mice (local field potentials) in which downregulation or upregulation of K channels is induced.

Skills:

• Engineering (computational, biomedical)
• Neurophysiology
• Neuroscience
• Neurology
• Computer Science (implementation of Python routines into an existing software application named COALIA

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TYPE OF JOB

TYPE OF CONTRACT

CDD (Temporary / 3 years) 

REMUNERATION

APPLICATION DEADLINE

EMPLOYMENT START DATE