KEY WORDS | neurophysiology, neurology, neuroscience |
CITY | Rennes |
COUNTRY | France |
DETAILS OF THE OFFER | Working place: INSERM U1099 Laboratoire du Traitement du Signal et de l'Image (LTSI) / the University of Rennes Missions: Context. Developmental and epileptic encephalopathies (DEEs) are a group of severe rare diseases where the combined effect of seizures, most often drug resistant, and the non-seizures consequences of the disease etiology, often genetic, entail a debilitating encephalopathy with drastic effects on the neurodevelopmental, psychiatric, and motor abilities of the patients. DEEs due to potassium channel mutations (K-DEEs) are emblematic of this disease presentation. Qualifiactions: The research project is at the interface between biomathematics (neuro-inspired models) and neuroscience/neurology (epilepsy). The Post-doc/Engineer fellow (PhD level) will preferably have a strong background in computational neuroscience/systems biology or in electrical engineering with experience in bio-signal processing. Knowledge in electrophysiology and/or EEG analysis would be an asset. The objective of the proposed research position is to design novel neuro-inspired models taking into account the molecular effect of a gene mutation on the specific voltage-gated potassium (K) channel function and the specific phenotypes observed in patients (scalp-recorded EEG signals) and in genetically-modified mice (local field potentials) in which downregulation or upregulation of K channels is induced. Skills:
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TYPE OF JOB | Thesis - PhD |
TYPE OF CONTRACT | CDD (Temporary / 3 years) |
REMUNERATION | The competitive salary will be according to experience (2300 Euros net, minimum). |
APPLICATION DEADLINE | 1 JUN 2024 |
EMPLOYMENT START DATE | 1 MAR 2024 |