PhD candidate in neurobiology and stem cells

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France

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Working place: CNRS / Institut de génomique fonctionnelle de Lyon

Missions:

The "Spatio-temporal Logic of Adult Neurogenesis" team is located within UMR 5242, at the Functional Genomics Institute of Lyon. (IGFL). It is a multidisciplinary institute, offering an interesting exposure to several model systems around common themes related to development, regeneration, evolution, and physiology. One of the strengths of the institute is the quality of the imaging facility and single-cell and spatial transcriptomics.
Our team is supported by the Foundation for Medical Research (FRM), ATIP-AVENIR, and ERC Starting Grants.

Title:

Spatiotemporal Dynamics of Adult Neural Stem Cells During Pregnancy and Motherhood

Context:

Research conducted over the past three decades has shown that new neurons can be generated in the adult brain and integrate into existing complex circuits. The process of adult neurogenesis is evolutionarily conserved among vertebrates, including fish, amphibians, reptiles, birds, rodents, and primates. It is supported by a small population of undifferentiated cells, called neural stem cells, which persist as embryonic vestiges in adult brains. These cells reside in tightly controlled microenvironments called "niches." In our team, we study the cellular and molecular mechanisms that allow distinct pools of neural stem cells to coordinate their behavior in space (through niches) and in time (from the embryo to different stages of adulthood), under specific physiological and pathological conditions.

Objective of the thesis project:
Pregnancy and motherhood in mammals are periods of significant brain plasticity. We will test the impact of these physiological states on the spatiotemporal dynamics of adult neurogenesis in mice across the two niches of the adult brain.

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