DETAILS OF THE OFFER | Working place: Paris-Saclay Neuroscience Institute Missions: Thesis Title: Ontogenesis of behavioural disorders and brain dysfunction in mouse models of Duchenne muscular dystrophy
To study the postnatal development and ontogeny of sensory, motor, behavioral, cognitive and neuropsychiatric deficits in mouse models of a neurodevelopmental pathology (Duchenne muscular dystrophy). To clarify the differential impact of two mutations leading to distinct neuropsychological profiles in patients. To characterize biochemical biomarkers of the brain cellular alterations associated with these deficits, and the age of onset of these alterations. Use the behavioral phenotypes and biomarkers identified to define an optimal therapeutic window and evaluate the impact of gene therapies aimed at compensating for these deficits.
Activities:
Postnatal behavior of mice, dissection and sampling of brain tissue, biochemical analyses (western blots), immunohistochemistry, confocal imaging, intracerebral injections.
Strong motivation for postnatal behavioral studies in mice, research at the interface between neuroscience and preclinical research, statistics applied to biology, ethics. Organization, rigor, diligence, team spirit, initiative, good writing skills in French and English, fluency in English.
+infos |
