Post-doctoral researcher in neural stem cell and infection

KEY WORDS

CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place: IRIM institute located on the CNRS campus of Montpellier

Missions:

We are looking for a talented and motivated scientist to join our team "Membrane Dynamics & Viruses" (MDV) led by Dr. Raphael Gaudin, part of the IRIM institute located on the CNRS campus of Montpellier, France. Our team has expertise in cellular neurobiology and virus infections (Partiot et al, Nat Microbiol, 2024; Partiot, Gorda et al, EMBO Mol Med, 2024; Phouphetlinthong et al, Lab Chip, 2023; Iwasaki et al, Brain Stim, 2024; Brychka et al, EMBO Rep, 2024). We are now looking for a dynamic candidate to integrate our team, bringing his/her expertise in neurobiology to lead a very ambitious project at the crossroad of several disciplines and at the frontier of current knowledge. The project includes culture of 2D stem cell derived neurons, 3D cerebral organoids and post-mortem human brain slices and electrophysiological measurement using microelectrode arrays (MEA) to monitor functional neuronal activity and synaptic homeostasis in physiological condition and upon viral infection. This international project will have a particular focus on neurodevelopmental perturbations associated to viral infections. The project is tightly bound to clinicians on the one hand, and to bioinformaticians on the other hand, to ensure that all expertise needed are synergizing to achieve our goals. Funding to hire a young post-doc for 2 years is available, with the aim to extend it, in order to complete the project with most successful outcome.

Activities:

Stem cell culture, differentiation and culture of neural stem cells and organoids, human tissue explant culture, electrical activity recording on microelectrode arrays (MEA) and analysis, immunostaining preparation and confocal microscopy imaging, classical molecular and cell biology techniques, RT-qPCR, western blot, flow cytometry, virus production.

Expected skills:

We are looking for a candidate with expertise in stem cell culture and neurobiology. Knowledge in electrophysiology, microscopy, or organoids is a plus. Good written and oral skills in English are required. French is not a prerequisite.

Context:

The proposed project will take place in the beautiful coastal city of Montpellier, in the south of France. The IRIM institute is located on the CNRS campus, gathering vibrant research labs specialized in cell biology, genetics, infectiology, neurobiology, ecology, and chemistry. The campus hosts high-end microscopy, flow cytometry and biosafety level 2 and 3 facilities. The candidate will benefit from a very dynamic workplace and a stimulating international scientific and social environment.

Our international team is composed of 15 members from diverse origins, showing interdisciplinary skills and developing a wide range of advanced biological knowledge in cell biology, virology and neurobiology. All lab interactions are in English, and include weekly labmeeting, internal and external seminars, institute and lab retreats. The team benefits from a friendly and supportive atmosphere, with the aim to achieve our goals in a publication-oriented, efficient and thorough manner. Promoting individuals' careers through experimental and conceptual mentoring is also a collective endeavor.

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