DETAILS OF THE OFFER | Working place:
The Brain Institute is a private foundation recognized for public benefit, dedicated to fundamental and clinical research on the nervous system. In one location, 850 researchers, engineers, and doctors cover all neurological disciplines to accelerate discoveries about brain function and develop treatments for conditions including Alzheimer's, Parkinson's, Multiple Sclerosis, epilepsy, depression, paraplegia, quadriplegia, and more.
Project Overview:
The research team focuses on cortical malformations caused by somatic mutations acquired during brain development. The main objective is to understand the molecular and cellular bases of cortical malformations associated with epilepsy. The methodology relies on modeling through the introduction of somatic mutations in mouse embryo brains via in utero electroporation (IUE).
Missions:
Main Responsibilities:
- Establish and characterize mouse models using IUE
- Perform surgeries and develop IUE protocols to target different brain structures
- Manage breeding in coordination with animal facility provider, administer antiepileptic molecules
- Perform cryostat sectioning, histology, immunohistochemistry, microscopy
- Analyze data, perform quantifications, and create figures for articles
- Prepare samples for scRNAseq and spatial transcriptomics
- Collaborate with ICM platforms for in vitro (MEA) and in vivo (EEG-video) electrophysiology
- Present results at team meetings and conferences
- Train students and newcomers in animal experimentation and histology
Responsibilities can be adapted based on candidate profile (IE or IR level)
Qualifications:
- Master's degree in Molecular and Cellular Neuroscience
- 3 years experience in animal experimentation
Technical Skills:
- Experience in mouse surgery
- Experience in immunolabeling and microscopy
- Knowledge of single-cell approaches and mouse brain
Required Skills:
- Proficiency in scientific English (oral and written)
Soft Skills:
- Ability to work independently and in an organized manner
- Strong scientific rigor
- Good interpersonal skills and ability to interact with team members
The Brain Institute is committed to fighting all forms of discrimination. We guarantee an inclusive work environment that respects all forms of diversity.
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