Postdoctoral researcher - Microbiota and Alzheimer's disease

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CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place: The Institute of Functional Genomics (IGF) / CNRS

Missions:

In close collaboration with M. Cissé's team in Nantes and as part of the ANR MICROCONNECT programme, this project will address the question of a causal relationship between dysbiosis and amyloid pathology on the one hand, and Alzheimer's disease symptoms and digestive comorbidity on the other, with the aim of identifying the bacterial mediators involved and deciphering their mechanisms of action. This project could pave the way for innovative treatments targeting the intestinal microbiota or downstream molecular partners.

Activities:

• Supervise a research project
• Design and perform experiments, including experimentation on mouse models (gavage, i.p. injections, blood sampling, oral and fecal microbiota sampling), behavioral testing, post-mortem neuropathology assessment, development and implementation of new experimental paradigms
• Analyze multi-omics data generated by CROs and platforms and correlate them with biological data.
• Analyze results and ensure their validity.

Qualifications:

• PhD in biology, neurobiology, microbiology or a related discipline.
• Previous experience in animal experimentation is essential.
• Experience in microbiota research would be highly appreciated.
• Knowledge of immunology or neuroinflammation will be valuable.
• A good understanding of bioinformatics and modelling models would be a plus.

Character traits and work ethic:

• Scientific rigor in the design of experiments and statistical analyses.
• Autonomy, organization and responsiveness in a fast-paced environment with a heavy workload.
• Ability to work independently while fostering team spirit.
• Strong communication skills to interact proactively with colleagues and foster an interdisciplinary environment.
• Excellent writing skills (reports, presentations, posters, manuscripts).
• Fluency in spoken French or English is mandatory.

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