Assistant engineer / ingénieur d'études in brain organoid research

KEY WORDS

CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place:  The "Laboratory of Mechanisms and Therapy of Genetic Brain Diseases"

The team:

Our team is dedicated to dissecting the molecular mechanisms of genetic brain disorders. We focus on understanding the link between rare genetic diseases and complex age-related disorders. Specifically, our research encompasses:

• Investigating the shared molecular pathways that underlie inflammatory, infectious, and neurodegenerative diseases.
• Identifying risk and resilience factors in neuronopathic mitochondrial and lysosomal diseases.

We use human pluripotent stem cell (iPSC) and long-term organoid culture models. Combined with single cell omics, these models help us identify the role of disease-related genetic variants. Our goal is to validate targets with significant diagnostic and therapeutic potential.
 

Missions:

The selected candidate will contribute to various research projects focused on understanding the physiopathology of genetic brain diseases. Utilizing cellular models, specifically iPSCs differentiated into organoids (brain, intestinal), the responsibilities include:

• Maintenance of iPSCs.
• Implementation of organoid differentiation protocols and initial characterization.
• Designing and conducting experiments in molecular biology, cell biology, and biochemistry.
• Implementing imaging techniques (for example, confocal microscopy)
• Lab management responsibilities including purchasing laboratory reagents, monitoring consumable spending, negotiating with vendors for the purchase of lab equipment and bulk quantity items

Qualifications:

• Strong neuroscience and/or cell biology background.
• Proficiency with molecular and cell biology techniques.
• Prior experience with cell culture; familiarity with iPSC technology and differentiation is a plus.
• Preference will be given to candidates with additional strong background in molecular biology and CRISPR/Cas9 gene editing.
• The ability to work independently, establish new techniques, interpret and discuss experiments is essential.
• Excellent organizational skills.
• Team-oriented and goal-driven mindset.
• Fluency in scientific English.
• Educational background: Masters or Engineering School.

TYPE OF JOB

TYPE OF CONTRACT

CDD (temporary / 2 years  with a possible extension / Fixed term contract for 12 months, possibility of extension)

REMUNERATION

EMPLOYMENT START DATE