Molecular and cellular mechanisms involved in motor neuron diseases

KEY WORDS

CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place: INCIA/Bordeaux University

Missions:

The project goals are to determine the functions and effects of different isoforms of genes, focusing on genes involved in motor neuron diseases with the aim of better understanding the molecular and cellular mechanisms involved in these disorders.

The postdoctoral researcher will have the objectives to:

• Study the functional role and intracellular localization of selected isoforms of genes by modification of their expression (overexpression or silencing) in various cell lines and human neurons derived from pluripotent stem cells.
• Generate long read RNASeq data from cell lines and neurons derived from IPSC from patients (in a platform or in the lab according to the skills of the postdoc) and correlate the mutation with the isoforms produced and the phenotype observed.

The work will be carried out in the team “Translational research in Neurogenetic diseases”, at the INCIA institute, located in the Neurocampus, Bordeaux, France.

INCIA is an Institute of the NEUROCAMPUS Bordeaux gathering 800 researchers on 6 research units.

Qualification:

• Independent management of the research project
• Data formatting and regular communication with the research team
• Scientific communication (writing of scientific publications, oral presentations)

Skills:

• At ease in cell culture (and/or differentiation of IPSC into neurons)
• Basic molecular biology for production of expression vectors
• +/- Bioinformatics analysis of RNAseq data and/or long-read sequencing (or willing to learn).

TYPE OF JOB

TYPE OF CONTRACT

CDD (temporary / 24 months)

EMPLOYMENT START DATE