Three-year PhD position in Neurosciences: pathogenic mechanisms in Alzheimer's disease

KEY WORDS

CITY

COUNTRY

France

DETAILS OF THE OFFER

Working place: Institute of Neuropathophysiology (INP), CNRS/Aix-Marseille University

Missions:

This position is funded by the Vaincre Alzheimer foundation, and the successful candidate is expected to start at the beginning of 2025.

Alzheimer’s disease (AD) represents one of the most significant scientific and socio-economic challenges of the 21st century. Hallmarks of AD include aggregates of amyloid-β (Aβ) and tau proteins, as well as neuroinflammation and gliosis, which collectively lead to synaptic and neuronal loss, forming the basis of cognitive decline.

The selected candidate will engage in a cutting-edge research project that seeks to elucidate the molecular mechanisms underlying microglia-driven neurodegeneration in AD. Specifically, the project will involve identifying proteomic differences and similarities in microglial reactivity induced by Aβ and tau pathologies, leveraging microglia-specific metabolic labeling of the proteome in Aβ and tau mouse models. The research will encompass the use of genetically modified mice and a range of techniques, including proteomics, biochemical assays, molecular and cell biology methods, as well as histopathological analysis.

The successful PhD candidate will be supervised by Dr. Maud Gratuze and will conduct the project at the Faculty of Medicine, located in the heart of Marseille.

Qualifications:

While not mandatory, prior knowledge or experience in the following areas will be highly valued: Alzheimer’s disease pathogenesis, Proteomics, Biochemical and molecular biology techniques, Cell culture, Confocal or super-resolution microscopy, Behavioral experiments.

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