Research Engineer Position in Brain Organoids

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Place of work: The Brain Institute

Missions:

Our research team studies the molecular and cellular mechanisms of epilepsies with cortical malformations caused by somatic mutations (PMID: 38710875, PMID: 36635388, PMID: 31444548). The approach is multidisciplinary, combining genetics with in vitro and in vivo modeling.

Main Project Objective: To elucidate the molecular and cellular bases of cortical malformations and epilepsy.

Methodology:

• Generation of brain organoids and assembloids in vitro
• Characterization of neurodevelopmental phenotype

Main Responsibilities:

As a research engineer, you will be responsible for:

• Establishing and characterizing iPSC lines and mosaicism
• Implementing 3D neuronal differentiation protocols to generate organoids and assembloids
• Performing cryostat sectioning, histology, immunohistochemistry, microscopy
• Analyzing data and performing quantifications
• Preparing samples for scRNAseq and spatial transcriptomics
• Interacting with ICM platforms for in vitro electrophysiology (MEA)
• Presenting results at team meetings and conferences

Responsibilities can be adapted based on candidate profile (IE or IR level)

Qualifications:

Master's degree in Molecular and Cellular Neuroscience
3 years experience in cell culture required

Technical Skills:

• Experience in cell culture, preferably with iPSCs and brain organoids
• Mastery of immunolabeling and microscopy techniques

Required Skills:

• Proficiency in scientific English (oral and written)

Soft Skills:

• Ability to work independently and in an organized manner
• Strong scientific rigor
• Good interpersonal skills and ability to interact with team members
• Scientific curiosity and ability to adapt to new technologies

The Brain Institute is committed to fighting all forms of discrimination. We guarantee an inclusive work environment that respects all forms of diversity.

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