Date d'arrivée à l'ITMO : Mercredi 08 Janvier 2025
Postdoctoral Fellow Position Available in Neurodegeneration Research
KEY WORDS
Parkinson's disease, neurons, neuroscience
CITY
Paris
COUNTRY
France
DETAILS OF THE OFFER
Working place: Centre de Neurosciences Intégratives et Cognition (INCC)
Project Overview:
Parkinson's disease is characterized by the dysfunction and degeneration of dopaminergic neurons. This project focuses on the role of late endosomal autophagic pathways in the secretome of neurons, with a particular emphasis on extracellular vesicles and mitovesicles.
Missions:
Using human induced pluripotent stem cells (iPSCs) carrying PD-associated mutations (LRRK2, αsynuclein), the successful candidate will:
Investigate the toxic effects of secretomes from mutant dopaminergic neurons and astrocytes on healthy neurons.
Explore the roles of VAMP7 and ATG5 in secretory and autophagic pathways.
Assess autoimmune responses via the neuronal immunopeptidome to uncover potential therapeutic targets.
This project is part of a collaborative effort between experts in neuronal cell biology and immunology (Sebastian Amigorena, Institut Curie), aiming to develop innovative therapeutic strategies that enhance degradative autophagy and identify new antigenic targets in PD.
Qualifications:
Hold a PhD in neuroscience, cell biology, or a related field (first postdoctoral position preferably).
Have hands-on experience with iPSC culture and differentiation into neural cell types.
Be proficient in advanced microscopy techniques (e.g., confocal, live-cell imaging).
Demonstrate a strong background in cell biology, particularly in autophagy and/or neurodegeneration.
Be enthusiastic, collaborative, and able to work independently in a multidisciplinary setting.
