PhD Position in Circulating Biomarkers of Brain Dysfunction in Myotonic Dystrophy Type 1

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Key Words myology, neuroscience, biomarkers

Details of the offer

Place of work: Inserm / U974 Centre of Research in Myology

Missions:

This PhD project aims to identify brain-specific biomarkers for monitoring disease progression and therapeutic response in myotonic dystrophy type 1 (DM1). Given the significant neurological impairments associated with DM1, the study will focus on analysing the secreted proteome, transcriptome, and metabolome of neurons and astrocytes to uncover potential biomarkers. Using primary cultures from a DM1 mouse model, the project will assess astrocyte secretome variations in response to therapeutic interventions, including antisense oligonucleotides (ASO) and decoy RNA-binding proteins.

The doctoral candidate will:

• Analyse secreted molecules in cell culture media
• Investigate the impact of DM1 astrocyte-derived signals on neurons
• Evaluate candidate biomarkers in the blood of DM1 mouse models and patient cohorts

Qualifications:

A highly motivated and ambitious DC with a strong knowledge in molecular and cellular biology. A keen interest in neurobiology, RNA-based therapeutics and biomarker discovery is essential. Applicants must hold a Master’s degree (or equivalent) in Molecular Life Sciences, Neuroscience, Biomedical Sciences, or a related field. Practical experience in molecular biology techniques (such as PCR, RT-PCR) and cell culture is required. Prior experience with transcriptomics and proteomics, as well as in vitro and/or in vivo disease models is highly desirable. 

The ideal candidate should demonstrate strong analytical and problem-solving skills, scientific curiosity, and a commitment to advancing therapeutic research. Excellent communication and teamwork abilities are essential for effective collaboration within a multidisciplinary and international research environment. Proficiency in English is mandatory, and some basic knowledge of French is recommended to facilitate broader institutional and social interactions.

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Type of job

Type of contract CDD

Application deadline

Employment start date 01/09/2025

Contact

Interested candidates should submit a single PDF document to Mario Gomes-Pereira (mario.pereira@inserm.fr) and recruitment.entrydm@gmail.com, named with your full name.

1. A detailed CV (maximum two pages), specifying educational background (name of university/universities, year degree(s) obtained, title(s) of degree(s)), qualifications, work experience, skills, research interests, list of publications (if any) and the names and contact details of two referees.
2. A motivation letter (maximum two pages), describing the candidate’s interest in the network, previous research experience, and current research interest outlining the fit to the desired PhD Project. If you are planning to apply to more than one position in the network, please limit your applications to three positions maximum (from DC1 to DC14) and please provide a separate document detailing which positions you have applied for. 
3. Copy of passport or National Identify Card.
4. Copies of academic certificates (BSc, MSc, and any other relevant diplomas), translated into English, including expected final grade and date.
5. Proof of English proficiency, demonstrated by IELTS, TOEFL, or a university certification confirming that the degree or MSc thesis was conducted in English.
6. Two recommendation letters (maximum 1 page each).

Only documents in English will be accepted.

Applications failing to include the requested documentation, who do not indicate the preferred projects or do not meet the eligibility criteria, will not be considered.