Key Words mouse, pathology, neuroscience
Details of the offer
Place of work: Institute of Molecular and Cellular Pharmacology / CNRS
Missions:
Post-doctoral researcher in charge of developing and conducting experimental protocols, as part of research projects on mouse models of neurological diseases linked to voltage-gated sodium channels. Sodium channel mutations are implicated in various types of neurodevelopmental disorders, including autism spectrum disorders and epileptic and developmental encephalopathies (DEEs, characterized by drug-resistant seizures, cognitive/behavioral deficits, movement disorders and mortality, often due to “sudden unexpected death in epilepsy” or SUDEP).
Activities:
- Electrophysiological recordings in brain slices and cultured cells (patch-clamp, LFP, electrical stimulations).
- Mouse interventions such as injections, pharmacological treatments, sampling, labeling and genotyping.
- Placement of electrodes to record cerebral electrophysiological signals.
- Quantification of epileptic seizures in mouse models and quantification of other physiological parameters.
- Perform behavioral tests on mice (basic quantification of cognitive functions, motor skills, social interactions, etc.).
- Formatting of results and statistical analysis.
- Literature monitoring and improvement/adaptation of techniques and analyses.
-
Qualifications:
- Experience in electrophysiological recordings (in particular ex vivo patch-clamp and in vivo ECoG).
- Experience in preparing slices for electrophysiological recordings.
- Mouse handling.
- Data analysis skills: statistical analysis, signal analysis (particularly electrophysiological).
- Training in animal experimentation.
- Organizational skills, rigor and method, motivation, autonomy.
- Knowledge of written and spoken English.
+info
Type of job
Type of contract CDD
Application deadline
Employment start date 15/07/2025
